Suppression of Ribosome Biogenesis by Targeting WD Repeat Domain 12 (WDR12) Inhibits Glioma Stem-Like Cell Growth
Glioma stem-like cells (GSCs) are a subset of tumor cells that initiate malignant growth and promote the therapeutic resistance of glioblastoma, the most lethal primary brain tumor.Ribosome biogenesis is an essential cellular process to maintain cell growth, but its regulatory Collagen mechanism in GSCs remains largely unknown.Here, we show that WD